INTERLEUKIN 16 IN THE SERUM BONE
Introduction. Progress in the treatment of cancer and bone tumors including, is associated with a significant breakthrough in molecular
biology, immunology, understanding the causes of the emergence of the tumor cell, patterns of the development and course of the tumor
process.
The aim of the study. The study of the levels of interleukin (IL) 16 in the serum of patients with bone tumors prior to treatment with a
particular account of the histological structure of the tumor and late fate of the treatment
Methods. Immunoassay.
Results. The detection rate of IL16 in serum of the patients with bone tumors was 93%, no significant differences in levels of IL16 if
considering the histological structure of tumor and stage malignant tumors were found. No relationship between the size of the primary tumor
and the content of IL16 in serum was revealed. Differences in survivability rates of patients with regard to the content in the IL16 serum
levels were determined before the beginning of a particular treatment. Overall 5-year survival value of osteosarcoma patients with the content
of IL16 in serum >33,0 pg/ml was 1,6 times, with Ewing's sarcoma – 1,7 times, while in chondrosarcoma – 1,8 times less than in patients
with IL16 content in the blood serum
Keywords:
osteosarcoma, chondrosarcoma, Ewing's sarcoma, IL16