STUDYING THE RELATIONSHIP OF COPPER AND ZINC CONCENTRATIONS IN BLOOD SERUM WITH INFLAMMATION MARKERS

DOI: https://doi.org/10.29296/24999490-2023-05-05

G.D. Morozova(1), E.D. Namiot(1), E.V. Rylina(1, 2), T.V. Korobeinikova(1, 2), A.A. Tsibulina(1), A.R. Sadykov(3), V.V. Yurasov(2), 3, A.V. Skalny(1, 2)
1-First Moscow State Medical University named after. THEM. Sechenov, (Sechenov University),
Trubetskaya st., 8, building 2, Moscow, 119991, Russian Federation;
2-Federal State Autonomous Educational Institution of Higher Education "Russian Peoples' Friendship University",
Miklouho-Maklaya st., 6, Moscow, 117198, Russian Federation;
3-Laboratory of Metabolomic Diagnostics, Starokaluzhskoe Shosse, 63, Moscow, 117630, Russia

Introduction. According to modern concepts, the inflammatory process is one of the key links in the development of cardiovascular, autoimmune, neurological, oncological diseases, as well as metabolic syndrome, complications of diabetes mellitus, and pathologies of the respiratory system. The implementation of a normal inflammatory response requires metabolic and cellular resources, the functionality of enzymatic and antioxidant systems, which, in turn, depends on the body’s supply of macro- and microelements. Research has shown that zinc and copper are some of the main elements associated with inflammation. Purpose of the study. The purpose of the study was to examine the relationship between serum copper and zinc concentrations and markers of inflammation. Material and methods. The study examined correlations between serum copper and zinc concentrations and various measures of inflammation in 1,153 people aged 18 to 86 years. The concentrations of CRP, ESR, ferritin, ceruloplasmin, leukocytes, neutrophils, fibrinogen, uric acid, copper, and zinc were determined in those examined. Serum microelements were measured by ICP-MS; other indicators were determined by standard methods. Correlation analysis was carried out using the Spearman coefficient. Results. The strongest statistically significant correlations (p
Keywords: 
inflammation, markers, blood serum, copper, zinc
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