THYROIDOGENESIS AND TRACE ELEMENTS: PREDICTOR POSSIBILITIES

DOI: https://doi.org/10.29296/24999490-2023-04-07

A.A. Logvinenko(1), G.D. Morozova(2), V.V. Poleschuk(3), A.R. Sadykov(4), V.V. Yurasov(4), A.V. Skalny(2, 5)
1-Private healthcare institution «Central clinical hospital «RZD-Medicine», Volokolamskoe sh., 84, Moscow, 125367, Russian Federation;
2-I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya str. 8/2, Moscow, 119991, Russian Federation;
3-Research Center of Neurology, Volokolamskoe sh., 80, Moscow, 125367, Russian Federation;
4-Laboratory of metabolomic diagnostics, Starokaluzhskoe sh. 63, Moscow, 117630, Russian Federation;
5-Peoples Friendship University of Russia, Mikluho-Maklaya str. 6, Moscow, 117198, Russian Federation

Introduction. Trace elements are widely involved in various metabolic processes in humans, including thyroid hormones. Iodine is a part of thyroid hormones, is actively involved in the work of thyroid enzymes, copper, zinc and manganese are included in the composition of antioxidant enzymes, which, in particular, in iron, need the synthesis of hormones. Purpose: to study the correlation between the levels of trace elements in the blood serum and thyroid hormones and TSH; determination of the prognostic sensitivity of the determination of trace elements, thyroid hormones and TSH in human serum. Material and methods. The study was performed on the basis of a database of analyzes collected in the course of laboratory practice. Iodine, selenium, copper, zinc, manganese were measured in blood serum by the ICP-MS method, thyroid hormones and TSH were measured by the immunochemiluminescent method. The total number of examined patients was 4162 people. In order to evaluate the quality of models for predicting deficiency or excess of an elevated ratio of thyroid hormones or TSH and vice versa, we used the ROC curve model, which is widely used to determine the diagnostic value of new markers. Results. The possibility of using TSH as a predictor of iodine deficiency in women was revealed. Also, the content of T4 can be predictors of iodine disease for sexes, and according to the content of total T3 and total T3 can only be predicted by iodine deficiency, also for sexes. Based on the study data, it was revealed that the concentration of thyroid hormones and TSH can be dangerous with the likelihood of an excess or deficiency of selenium, copper, zinc in both women and men. In turn, the level of thyroid hormones and TSH can be called as a predictor of excess or deficiency of sugar in the blood. Conclusion. Trace elements play an important role in thyroidogenesis and may be useful in the diagnosis and detection of cases of thyroid disease.
Keywords: 
hyroid gland, prediction, trace elements, iodine, zinc, blood serum
Список литературы: 
  1. Zhou Q., Xue S., Zhang L., Chen G. Trace elements and the thyroid. Frontiers in Endocrinology. 2022; 13: 904889. DOI: 10,3389/fendo.2022.904889
  2. Wroblewski M., Wroblewska J., Nuszkiewicz J., Pawlowska M., Wesolowski R., Woźniak A. The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases. International Journal of Molecular Sciences. 2023; 24 (5): 4840, DOI: 10,3390/ijms24054840
  3. Mullur R., Liu Y. Y., Brent G. A. Thyroid hormone regulation of metabolism. Physiological reviews. 2014; 94 (2): 355–82. DOI: 10,1152/physrev.00030,2013
  4. Авцын А. П., Жаворонков А.А., Риш М.А., Строчкова Л.С. Микроэлементозы человека: этиология, классификация, органопатология. М.: Медицина, 1991; 496.
  5. [Avcyn A. P., Zhavoronkov A.A., Rish M.A., Strochkova L.S. Human microelementoses: etiology, classification, organopathology. M.: Medicina, 1991; 496 (in Russian)].
  6. Maouche N., Meskine D., Alamir B., Koceir E. A. Trace elements profile is associated with insulin resistance syndrome and oxidative damage in thyroid disorders: Manganese and selenium interest in Algerian participants with dysthyroidism. Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements (GMS). 2015; 32: 112–21. DOI: 10,1016/j.jtemb.2015.07.002
  7. Cooper D.S. Subclinical thyroid disease: consensus or conundrum? Clin Endocrinol (Oxf). 2004; 60 (4): 410–2. DOI: 10,1111/j.1365-2265.2004.02031.x
  8. Köhrle J. Selenium and the thyroid. Current Opinion in Endocrinology & Diabetes and Obesity. 2015; 22 (5): 392–401. DOI: 10,1097/MED. 0000000000000190
  9. Rayman M. P. Selenium and human health. The Lancet. 2012; 379 (9822): 1256–68. DOI: 10,1210/jcem.87.4.8421
  10. Guastamacchia E., Giagulli V.A., Licchelli B., Triggiani V. Selenium and Iodine in Autoimmune Thyroiditis. Endocr Metab Immune Disord Drug Targets. 2015; 15 (4): 288–92. DOI: 10,2174/1871530315666150619094242
  11. Hordyjewska A., Popiołek Ł., Kocot J. The many “faces” of copper in medicine and treatment. Biometals. 2014; 27: 611–21. DOI: 10,1007/s10534-014-9736-5
  12. Strausak D., Mercer J. F., Dieter H. H., Stremmel W., Multhaup, G. Copper in disorders with neurological symptoms: Alzheimer’s, Menkes, and Wilson diseases. Brain research bulletin. 2001; 55 (2): 175–85. DOI: 10,1016/s0361-9230(01)00454-3
  13. Severo J. S., Morais J. B. S., de Freitas T. E. C., Andrade A. L. P., Feitosa M. M., Fontenelle L. C., de Oliveira A. R. S., Cruz K. J.C., do Nascimento Marreiro, D. The role of zinc in thyroid hormones metabolism. International Journal for Vitamin and Nutrition Research. 2019; 89 (1–2): 80–8. DOI: 10,1024/0300-9831/a000262
  14. Hirano T., Murakami M., Fukada T., Yamasaki S., Nishida K., Suzuki T. Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule. Advances in immunology. 2008; 97: 149–76. DOI: 10,1016/S0065-2776(08)00003-5
  15. Григорьев С.Г., Лобзин Ю.В., Скрипченко Н.В. Роль и место логистической регрессии и ROC-анализа в решении медицинских диагностических задач. Журнал инфектологии. 2016; 8 (4): 36–45. DOI: 10,22625/2072-6732-2016-8-4-36-45
  16. [Grigoryev S.G., Lobzin Yu.V., Skripchenko N.V. The role and place of logistic regression and ROC-analysis in solving medical diagnostic problems. Zhurnal infektologii. 2016; 8 (4): 36–45. DOI: 10,22625/2072-6732-2016-8-4-36-45 (in Russian)].
  17. Donangelo I., Suh S.Y. Subclinical hyperthyroidism: when to consider treatment. American family physician. 2017; 95 (11): 710–6.
  18. Bekkering G. E., Agoritsas T., Lytvyn L., Heen A. F., Feller M., Moutzouri E., Abdulazeem H., Aertgeerts B., Beecher D., Brito J.P., Farhoumand P.D., Singh Ospina N., Rodondi N., van Driel M., Wallace E., Snel M., Okwen P.M. , Siemieniuk R., Vandvik P.O., Kuijpers T., Vermandere M. Thyroid hormones treatment for subclinical hypothyroidism: a clinical practice guideline. Bmj. 2019; 365: l2006. DOI: 10,1136/bmj.l2006
  19. Wu Q, Rayman M P, Lv H, Schomburg L, Cui B, Gao C, Chen P, Zhuang G, Zhang Z, Peng X, Li H, Zhao Y, He X, Zeng G, Qin F, Hou P, Shi B. Low population selenium status is associated with increased prevalence of thyroid disease. J Clin Endocrinol Metab. 2015; 100 (11): 4037–47. DOI: 10,1210/jc.2015-2222
  20. Derumeaux H., Valeix P., Castetbon K., Bensimon M., Boutron-Ruault M. C., Arnaud J., Hercberg S. Association of selenium with thyroid volume and echostructure in 35-to 60-year-old French adults. European Journal of Endocrinology. 2003; 148 (3): 309–15. DOI: 10,1530/eje.0,1480309
  21. Błażewicz A., Wiśniewska P., Skórzyńska-Dziduszko K. Selected essential and toxic chemical elements in hypothyroidism—a literature review (2001–2021). International J. of Molecular Sciences. 2021; 22 (18): 10147. DOI: 10,3390/ijms221810147
  22. Krishnamurthy H.K., Reddy S., Jayaraman V., Krishna K., Song Q., Rajasekaran K.E., Wang T., Bei R., Rajasekaran J.J. Effect of micronutrients on thyroid parameters. J. of Thyroid Research. 2021: 1865483. DOI: 10,1155/2021/1865483
  23. Ertek S., Cicero A. F., Caglar O., Erdogan G.. Relationship between serum zinc levels, thyroid hormones and thyroid volume following successful iodine supplementation. Hormones. 2010; 9, 263–8.
  24. El-Fadeli S., Bouhouch S., Skalny A. V., Barkouch Y., Pineau A., Cherkaoui M., Sedki A. Effects of imbalance in trace element on thyroid gland from moroccan children. Biological trace element research. 2016; 170: 288–93. DOI: 10,1007/s12011-015-0485-2
  25. Skrajnowska D., Bobrowska-Korczak B. Role of zinc in immune system and anti-cancer defense mechanisms. Nutrients. 2019; 11 (10): 2273.
  26. Memon N. S., Kazi T. G., Afridi H. I., Baig J. A., Sahito O. M., Baloch S., Waris M. Correlation of manganese with thyroid function in females having hypo-and hyperthyroid disorders. Biological trace element research. 2015; 167: 165–71. DOI: 10,1007/s12011-015-0277-8
  27. Stojsavljević A., Trifković J., Rasić-Milutinović Z., Jovanović D., Bogdanović G., Mutić J., Manojlović D. Determination of toxic and essential trace elements in serum of healthy and hypothyroid respondents by ICP-MS: A chemometric approach for discrimination of hypothyroidism. J Trace Elem Med Biol. 2018; 48: 134–40, DOI: 10,1016/j.jtemb.2018.03.020