PROTEINS TIMP-2, IRISIN AND SITUATION WITH HEMOSTASIS, LIPID METABOLISM AND SEX HORMONES IN FEMALE CARDIOVASCULAR PATIENTS

DOI: https://doi.org/10.29296/24999490-2023-04-01

E.S. Guseva(2), B.I. Kuznik(1, 2), N.V. Lareva(1), Y.N. Smolyakov(1, 2), N.I. Chalisova(3, 4)
1-Chita State Medical Academy, Gorky str., 39 «a», Chita, 672000, Russian Federation;
2I-nnovative Clinic Academy of Health, Kohanovskogo str., 13, Chita, 672000, Russian Federation;
3-I.P. Pavlov Institute of Physiology of the Russian Academy of Sciences, nab. Makarova, 6, St. Petersburg, 199034, Russian Federation;
4-St. Petersburg Institute of Bioregulation and Gerontology, Dynamo Ave., 3, Saint Petersburg, 197110, Russian Federation

Introduction. The study of the level of the so-called «youth proteins» TIMP-2 and irisin in diseases of the cardiovascular system is not only of theoretical interest, but also of practical importance, as it outlines new ways to treat these diseases. Purpose of study was to summarize the literature data and also the authors presentation of proper results of a study of the changes in TIMP-2 and irisin levels and their relation to the indicators of the cardiovascular system activity, lipid metabolism, hemostasis system and sex hormones level in female hypertensive patients (HP). Material and methods. The investigation was in women group treated with drugs (HP-1) and in women group systematically taking, over several years, at least 3 courses of kinesiotherapy (HP-2). Relatively healthy women of the same age served as the control group. Results. TIMP-2 level was found to increase in the GB-1 group and to return to normal in the GB-2 group. Similar data were obtained for other cardiovascular diseases as well. Irisin concentration in HP-1 and HP-2 patients does not change in comparison to the control group. Conclusion. Literature data on irisin content in case of cardiovascular diseases are contradictory. However the authors of this study found the relationships in the control group, in HP-1 and HP-2 patients, between the levels of TIMP-2 and irisin, on the one hand, and cardiovascular system functions, as well as values of lipid spectrum, hemostasis, and sex hormones, on the other.
Keywords: 
youth proteins, cardiovascular diseases, sex hormones
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