POLYPEPTIDE EFFECT ON STIMULATION OF EXPERIMENTAL ANIMALS CELLULAR PROLIFERATION

DOI: https://doi.org/10.29296/24999490-2023-03-05

G.A. Ryzhak(2), N.I. Chalisova(1, 2), P.N. Ivanova(2), E.S. Egozova(3)
1-Pavlov Institute of Physiology of the Russian Academy of Sciences, nab. Makarova, 6, St. Petersburg, 199034, Russian Federation;
2-Saint Petersburg Institute of Bioregulation and Gerontology, Ave. Dinamo 3, St. Petersburg, 197110, Russian Federation;
3-Herzen State Pedagogical University of Russia, emb. Moika 48, St. Petersburg, 191186, Russian Federation

Introduction. The study of mechanisms of multicellular system regulation and of cellular proliferation and apoptosis balanced status in the organism tissues is one of the actual task of modern biology and medicine. Purpose of study. Effect of polypeptide complexes (PPCs) from liver (Wentwil) and of bladder (Wesustim). and of corresponding short peptides. on the cellular proliferation in liver and bladder tissues of mammalian and birds. Methods. Organotypic tissue culture of rat and 17-days chick embryo liver, bladder under different PPCs and short peptides was used for quick biologically activity of peptides screening. Results. The tissue specific effect of PPC and short peptides on liver and bladder of different animals types. The square index (SI) of explants was increased statistically reliable on 21–29%, as compared to the control. Conclusion. The data obtained produce the base for working and quick testing of preparations for treatment of patients with pathology in liver and bladder tissues.
Keywords: 
polypeptide complexes, short peptides, organotypic tissue culture
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