FEATURES OF EXPERIMENTAL OSTEOARTHROSIS CAUSED BY DEXAMETHASONE AND TALC

DOI: https://doi.org/10.29296/24999490-2023-01-07

S.O. Osmanova, O.O. Osmanov, A.A. Alimkhanova
Dagestan State Medical University, pl. Lenina 1, Makhachkala, 367000, Russian Federation

Introduction. An experimental study of the pathogenetic mechanisms of the development of inflammatory-destructive changes in the joints in animal models was carried out in order to develop new diagnostic strategies for further implementation of the results obtained in clinical practice, determination of morphometric and metabolic features of the skeletal connective tissue of the rat knee joints. Material and methods. The authors studied histological preparations of knee joints stained with Mayer’s hematoxylin and eosin, alcian blue (pH 1.0 and 2.5) according to Van Gieson, Masson and Mallory. The metabolic properties of cartilage and bone tissue were studied by determining the concentration of hyaluronic acid, osteocalcin, and type I collagen in the blood serum of laboratory animals. Results. In rats with osteoarthritis induced by the administration of dexamethasone and talc, a 50% decrease in the thickness of the articular cartilage in its loaded areas was noted. There was also a violation of the spatial distribution of chondrocytes, a decrease (p
Keywords: 
dexamethasone, articular cartilage, osteoarthritis, rats, chondrocytes
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