THE EFFECT OF TUBERCULOSIS ON THE COURSE OF LUNG CARCINOMA IN THE EXPERIMENT

DOI: https://doi.org/10.29296/24999490-2023-01-06

G.G. Kudriashov(1), A.O. Nefedov(1), G.V. Tochilnikov(2), Yu.G. Zmitrichenko(2), Yu.S. Krylova(1), M.Z. Dogonadze(1),
N.V. Zabolotnyh(1), P.V. Gavrilov(1), A.A. Azarov(1), E.A. Davydenkova(1), T.I. Vinogradova(1), P.K. Yablonskiy(1),
1Saint-Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation,
Ligovsky av., 2–4, St. Petersburg, 191036, Russian Federation;
2N.N. Petrov National Medicine Research Center of oncology,
Leningradskaya str., 68, village Pesochny, St. Petersburg, 197758, Russian Federation

Introduction. One of the problems of modern medicine is the low efficiency of treatment of patients with a coexistence of lung cancer and active tuberculosis. Optimal treatment regimens for coexistence pathology have not been developed at present. In recent years, fundamental research aimed to studying the unexplained mechanisms of the occurrence and course of coexistence pathology. The aim of the study was to investigate the peculiarities of the effect of tuberculosis with different drug resistance on the course of lung carcinoma in an experiment. Methods. The study was performed on 72 mice of the C57BL/6 line at the age of two months. To achieve the goal, three groups of laboratory animals were formed: Group 1 – mice infected with the reference strain Mycobacterium tuberculosis H37Rv, which underwent isolated transplantation of Lewis lung epidermoid carcinoma (n=24); Group 2 – mice infected with the clinical strain Mycobacterium tuberculosis 5582 with multidrug resistance, which underwent isolated transplantation of epidermoid lung carcinoma Lewis (n=24); Group 3 – uninfected mice that underwent isolated transplantation of Lewis lung epidermoid carcinoma (n=24). Clinical, radiological, morphological and bacteriological methods were used to compare the studied groups of animals. Statistical analysis was performed using the SPSS Statistica v23 software package. Results. In group 3, there was significantly (p
Keywords: 
coexistence of lung cancer and tuberculosis, experimental model, influence of tuberculosis on the course of carcinoma
Список литературы: 
  1. Ye M.F., Su S., Huang Z.H., Zou J.J., Su D.H., Chen X.H., Zeng L.F., Liao W.X., Huang H.Y., Zeng Y.Y., Cen W.C., Zhang X.L., Liao C.X., Zhang J., Zhang Y.B. Efficacy and safety of concurrent anti-tuberculosis treatment and chemotherapy in lung cancer patients with co-existent tuberculosis. Ann Transl Med. 2020; 8 (18): 1143. DOI: 10.21037/atm-20-5964.
  2. Lee C.S., Shu C.C., Chen Y.C., Liao K.M., Ho C.H. Treatment Incompletion of Tuberculosis in Patients with Lung Cancer: the Occurrence and Prediction Factors. International Journal of Infectious Diseases: IJID: Official Publication of the International Society for Infectious Diseases. 2021; 113: 200–6.
  3. Крылова Ю.С., Кудряшов Г.Г., Нефедов А.О., Дохов М.А., Захарченко А.О., Яблонский П.К. Сигнальные молекулы опухолевой трансформации при туберкулезе. Молекулярная медицина. 2022; 20 (6): 12–15. https://doi.org/10.29296/24999490-2022-06-02 [Krylova Yu.S., Kudriashov G.G., Nefedov A.O., Dokhov M.A., Zakharchenko A.O., Yablonskii P.K. Signaling molecules of tumor transformation in tuberculosis. Molekulyarnaya meditsina. 2022; 20 (6): 12–15 https://doi.org/10.29296/24999490-2022-06-02 (in Russian)].
  4. Кудряшов Г.Г., Нефедов А.О., Точильников Г.В., Змитриченко Ю.Г., Крылова Ю.С., Догонадзе М.З., Заболотных Н.В., Дьякова М.Е., Эсмедляева Д.С., Витовская М.Л., Гаврилов П.В., Азаров А.А., Журавлев В.Ю., Виноградова Т.И., Яблонский П.К. Оригинальная экспериментальная модель туберкулеза и рака легкого. Педиатр. 2022: 13 (5): 33–42. DOI: https://doi.org/10.17816/PED13533-42 [Kudrjashov G.G., Nefedov A.O., Tochil’nikov G.V., Zmitrichenko Ju.G., Krylova Ju.S., Dogonadze M.Z., Zabolotnyh N.V., D’jakova M.E., Jesmedljaeva D.S., Vitovskaja M.L., Gavrilov P.V., Azarov A.A., Zhuravlev V.Ju., Vinogradova T.I., Jablonskij P.K. Original’naja jeksperimental’naja model’ tuberkuleza i raka legkogo. Pediatr. 2022: 13 (5): 33–42. DOI: https://doi.org/10.17816/PED13533-42 (in Russian)].
  5. Вершинина С.Ф., Стуков А.Н. Экспериментальные опухоли: Практическое руководство. СПб.: Изд-во Галаника, 2018. [Vershinina S.F., Stukov A.N. Jeksperimental’nye opuholi: Prakticheskoe rukovodstvo. SPb.: Izd-vo Galanika, 2018 (in Russian)]