STUDY OF THE RELATIONSHIP OF IRON CONCENTRATION WITH THE FERRITIN AND TRANSFERRIN IN BLOOD SERUM

DOI: https://doi.org/10.29296/24999490-2023-01-05

V.V. Yurasov(1), A.R. Sadykov(1), G.D. Morozova(2, 3), E.D. Namiot(3), A.A. Logvinenko(4), A.V. Skalny(3, 5)
1-Laboratory of metabolomic diagnostics, Starokaluzhskoe sh. 63, Moscow, 117630, Russian Federation;
2-Golikov Research Center of Toxicology, Bekhtereva str. 1, St. Petersburg, 192019, Russian Federation;
3-I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaya str. 8/2, Moscow, 119991, Russian Federation;
4-Private healthcare institution «Central clinical hospital «RZD-Medicine», Volokolamskoe sh., 84, Moscow, 125367, Russian Federation;
5Peoples Friendship University of Russia, Mikluho-Maklaya str. 6, Moscow, 117198, Russian Federation

Introduction. Iron is one of the main elements for the vital activity of the body. Iron deficiency leads to the development of iron deficiency anemia, one of the most common diseases in the Russian Federation; excess iron induces oxidative stress. In this way, the diagnostics of iron metabolism is an important applied problem. The aim of the study. The aim of the study was to establish reference intervals for serum iron, measured not by the routine method, but by the ICP-MS method, on a large sample; study of gender and age fluctuations of the level of serum iron; study of the relationship between the concentration of iron and the levels of ferritin and transferrin in the blood serum. Material and methods. The study was performed on the basis of a database of laboratory analyzes. The number of laboratory tests for ferritin, transferrin, iron in serum was 6786, 1809, 13161, respectively. When determining the reference intervals, the Hoffman method was used. Results. It was found that the concentration of iron in the blood serum among women is lower than among men, and this tendency persists up to 45–50 years, there are no differences in the later age period. The concentration of serum iron positively and statistically significantly correlates with the level of ferritin in all age groups in the total sample and in the group of women; among men, statistically significant positive correlations were found only in the age groups of 18–25 years and older than 56 years. Correlations of iron concentration with the level of transferrin are less intense: statistically significant correlations were found in the total sample in the age groups of 26–35 years and 46–55 years. Conclusion. When calculating the reference intervals of serum iron, it is necessary to consider the gender and age dynamics of deviations. Aging processes have a greater impact on iron metabolism for women than for men.
Keywords: 
iron, ferritin, transferrin, blood serum, reference values, ICP-MS
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