THE USE OF MESENCHYMAL STEM CELLS IN THE TREATMENT OF OSTEOARTHRITIS

DOI: https://doi.org/10.29296/24999490-2023-01-02

A.I. Greben(1, 2), D.Yu. Shestakov(3), P.S. Eremin(2), E.Yu. Kostromina(2), P.A. Markov(2), T.N. Greben(2), I.R. Gilmutdinova(2)
1-Pirogov Russian National Research Medical University, st. Ostrovityanova, h.1. Moscow, 117997, Russian Federation;
2-National Medical Research Center for Rehabilitation and Balneology, st. Novyi Arbat, h.32, Moscow, 1221099, Russian Federation;
3-GBUZ Moscow Clinical Scientific Center named after A.S. Loginov DZM, highway Enthusiasts, 86, Moscow, 111123, Russian Federation

The purpose of the study was to analyze literature data on the use of mesenchymal stem cells as a conservative treatment of osteoarthritis. Material and methods. Literature search was carried out using keywords: traumatology, orthopedics, mesenchymal stem cells, osteoarthritis, cell therapy. Out of 300 selected articles, 60 were used to write a review. Results. Osteoarthritis treatment with mesenchymal stem cells has been shown to be effective and safe in cartilage repair in both animal and human studies. The review presents new literature data on therapeutic action mechanisms and elements of mesenchymal stem cells. Conclusion. The analysis shows that a positive experience of using mesenchymal stem cells (MSCs’) for osteoarthritis treatment. However, before mesenchymal stem cells take their place in practical tools arsenal a lot of work must be done, specifically: phase III of clinical trials, clear criteria development defining cell culture as MSCs, development of production standards and further study of MSCs’ mechanism of action in osteoarthritis.
Keywords: 
traumatology, orthopedics, mesenchymal stem cells, osteoarthritis, cell therapy
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